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The evidence that COVID-19 does not worsen after treatment with plasma from convalescent patients has been substantially reinforced by a study of 20,000 patients who were severely ill with the disease, showing an adverse event incidence of 13% 81

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However, while this dual mechanism of drug delivery and ROS-generation enhances antitumour efficacy, the potential for off-target oxidative damage to healthy brain cells and associated neurotoxicity was not comprehensively evaluated, which may in-turn limit translational interpretation